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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8846739 B1

PDFFull Text
Date of Patent:
Sep. 30, 2014

Filed:

Aug. 11, 2010

Tgr5 agonists

Applicants:

Venkataiah Bollu, San Diego, CA (US);

Brant Clayton Boren, San Diego, CA (US);

Jackaline Dalgard Julien, Del Mar, CA (US);

Brenton T. Flatt, Poway, CA (US);

Nadia Haq, Waltham, MA (US);

Sarah Hudson, San Diego, CA (US);

Raju Mohan, Encinitas, CA (US);

Michael Morrissey, Danville, CA (US);

Benjamin Pratt, Encinitas, CA (US);

Inventors:

Venkataiah Bollu, San Diego, CA (US);

Brant Clayton Boren, San Diego, CA (US);

Jackaline Dalgard Julien, Del Mar, CA (US);

Brenton T. Flatt, Poway, CA (US);

Nadia Haq, Waltham, MA (US);

Sarah Hudson, San Diego, CA (US);

Raju Mohan, Encinitas, CA (US);

Michael Morrissey, Danville, CA (US);

Benjamin Pratt, Encinitas, CA (US);

Assignee:

Exelixis Patent Company LLC, South San Francisco, CA (US);

Attorneys:

Honigman Miller Schwartz and Cohn LLP

Heidi Berven

Jonathan P. O'Brien

Primary Examiner:

Jeffrey S Lundgren

Assistant Examiner:

Meghan Finn

Int. Cl.
CPC ...
C07D 249/10 (2006.01); C07D 249/08 (2006.01); C07D 233/54 (2006.01); C07D 401/12 (2006.01); A61K 31/454 (2006.01); A61K 31/496 (2006.01); A61K 31/4995 (2006.01); C07D 295/15 (2006.01); C07D 249/12 (2006.01); A61K 31/4164 (2006.01); A61K 31/4178 (2006.01); A61K 31/5377 (2006.01); A61K 31/4196 (2006.01); C07D 403/12 (2006.01); C07D 233/64 (2006.01); C07D 233/84 (2006.01); A61K 31/4439 (2006.01); C07D 487/08 (2006.01);
U.S. Cl.
CPC ...
C07D 487/08 (2013.01); C07D 401/12 (2013.01); A61K 31/454 (2013.01); A61K 31/496 (2013.01); A61K 31/4995 (2013.01); C07D 295/15 (2013.01); C07D 249/12 (2013.01); A61K 31/4164 (2013.01); A61K 31/4178 (2013.01); A61K 31/5377 (2013.01); A61K 31/4196 (2013.01); C07D 403/12 (2013.01); C07D 233/64 (2013.01); C07D 233/84 (2013.01); A61K 31/4439 (2013.01);
Abstract

TGR5 agonists of structural formula VIII(Q), wherein X, R, R, and Rare defined in the specification, pharmaceutically acceptable salts thereof, compositions thereof, and use of the compounds and compositions for treating diseases. The invention also comprises use of the compounds in and for the manufacture of medicaments, particularly for treating diseases.

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