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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8846681 B1

PDFFull Text
Date of Patent:
Sep. 30, 2014

Filed:

Jun. 14, 2011

Pyrimidyl cyclopentanes as akt protein kinase inhibitors

Applicants:

Ian S. Mitchell, Lafayette, CO (US);

James F. Blake, Longmont, CO (US);

Rui Xu, Longmont, CO (US);

Nicholas C. Kallan, Boulder, CO (US);

Dengming Xiao, Longmont, CO (US);

Keith Lee Spencer, Lyons, CO (US);

Josef R. Bencsik, Longmont, CO (US);

Eli M. Wallace, Lyons, CO (US);

Stephen T. Schlachter, Boulder, CO (US);

Anna L. Banka, Longmont, CO (US);

Jun Liang, Palo Alto, CA (US);

Brian Safina, Redwood City, CA (US);

Jun LI, Foster City, CA (US);

Christine Chabot, San Mateo, CA (US);

Inventors:

Ian S. Mitchell, Lafayette, CO (US);

James F. Blake, Longmont, CO (US);

Rui Xu, Longmont, CO (US);

Nicholas C. Kallan, Boulder, CO (US);

Dengming Xiao, Longmont, CO (US);

Keith Lee Spencer, Lyons, CO (US);

Josef R. Bencsik, Longmont, CO (US);

Eli M. Wallace, Lyons, CO (US);

Stephen T. Schlachter, Boulder, CO (US);

Anna L. Banka, Longmont, CO (US);

Jun Liang, Palo Alto, CA (US);

Brian Safina, Redwood City, CA (US);

Jun Li, Foster City, CA (US);

Christine Chabot, San Mateo, CA (US);

Assignees:

Array BioPharma, Inc., Boulder, CO (US);

Genentech, Inc., South San Francisco, CA (US);

Attorney:

Viksnins, Harris & Padys PLLP

Primary Examiner:

Susanna Moore

Int. Cl.
CPC ...
A61K 31/497 (2006.01); A61P 25/16 (2006.01); A61P 35/00 (2006.01); A61P 29/00 (2006.01); A61P 9/00 (2006.01); A61P 25/28 (2006.01); C07D 405/12 (2006.01); C07D 403/12 (2006.01); C07D 409/12 (2006.01); C07D 401/12 (2006.01); C07D 403/04 (2006.01); C07D 239/70 (2006.01); C07D 401/14 (2006.01); C07D 403/14 (2006.01); C07D 405/14 (2006.01); C07D 409/14 (2006.01); C07D 407/14 (2006.01);
U.S. Cl.
CPC ...
C07D 239/70 (2013.01); C07D 405/12 (2013.01); C07D 403/12 (2013.01); C07D 409/12 (2013.01); C07D 401/12 (2013.01); C07D 403/04 (2013.01);
Abstract

The present invention provides compounds of Formula I, including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.

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