The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 30, 2014
Filed:
Jan. 20, 2011
Irina Apostolou, Roslindale, MA (US);
Paul Ponath, San Francisco, CA (US);
Joe Ponte, Quincy, MA (US);
Michael Rosenzweig, Boston, MA (US);
Lou Vaickus, Hingham, MA (US);
Irina Apostolou, Roslindale, MA (US);
Paul Ponath, San Francisco, CA (US);
Joe Ponte, Quincy, MA (US);
Michael Rosenzweig, Boston, MA (US);
Lou Vaickus, Hingham, MA (US);
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Abstract
Disclosed herein are methods of using anti-ILT5 antibodies and ILT5-binding fragments thereof to induce an immunostimulatory effect in a T cell when such a T cell is contacted with an antigen presenting cell (APC) that has been previously contacted with the anti-ILT5 antibody or ILT5-binding fragment. Also disclosed herein are methods of using anti-ILT5 antibodies and ILT5-binding fragments thereof to inhibit a response in a T cell (e.g., a pro-liferative response) when such a T cell is concomitantly contacted, or has previously been contacted, with an APC, which APC is simultaneously contacted with the anti-ILT5 antibody or ILT5-binding fragment. Also disclosed herein are methods of using anti-ILT5 antibodies and ILT5-binding fragments thereof for the treatment of various diseases and for use as immunostimulatory adjuvants.