The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 30, 2014

Filed:

Aug. 27, 2012
Applicants:

Jonathan Liu, Milpitas, CA (US);

Richard Schwartz, Bethesda, MD (US);

Mark Thompson, Morgan Hill, CA (US);

Luis Maranga, Santa Clara, CA (US);

Mridul Ghosh, San Jose, CA (US);

Ajit Subramanian, Berkeley, CA (US);

Simon Sheng-tsiung Hsu, Palo Alto, CA (US);

Inventors:

Jonathan Liu, Milpitas, CA (US);

Richard Schwartz, Bethesda, MD (US);

Mark Thompson, Morgan Hill, CA (US);

Luis Maranga, Santa Clara, CA (US);

Mridul Ghosh, San Jose, CA (US);

Ajit Subramanian, Berkeley, CA (US);

Simon Sheng-Tsiung Hsu, Palo Alto, CA (US);

Assignee:

MedImmune, LLC, Gaithersburg, MD (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/145 (2006.01); A01N 65/00 (2009.01); A61K 39/00 (2006.01); C12N 5/02 (2006.01); C07K 17/00 (2006.01); C12N 7/00 (2006.01);
U.S. Cl.
CPC ...
C12N 7/00 (2013.01); C12N 2760/16251 (2013.01); C12N 2760/16252 (2013.01); C12N 2760/16152 (2013.01); C12N 2760/16151 (2013.01);
Abstract

The present invention relates to novel MDCK cells which can be to grow viruses, e.g., influenza viruses, in cell culture to higher titer than previously possible. The MDCK cells can be adapted to serum-free culture medium. The present invention further relates to cell culture compositions comprising the MDCK cells and cultivation methods for growing the MDCK cells. The present invention further relates to methods for producing influenza viruses in cell culture using the MDCK cells of the invention.


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