The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 23, 2014
Filed:
Jul. 14, 2011
Siva Rama Prasad Vellenki, Hyderabad, IN;
Arabinda Sahu, Hyderabad, IN;
Nitin Ashok Shimpi, Hyderabad, IN;
Anil Ponnuru, Hyderabad, IN;
Satish Babu Kothari, Hyderabad, IN;
Siva Rama Prasad Vellenki, Hyderabad, IN;
Arabinda Sahu, Hyderabad, IN;
Nitin Ashok Shimpi, Hyderabad, IN;
Anil Ponnuru, Hyderabad, IN;
Satish Babu Kothari, Hyderabad, IN;
Mylan Laboratories Limited, Hyderabad, IN;
Abstract
The present invention relates to a novel process for the preparation of (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol of formula I by reacting a compound of formula VII with the compound of formula R2-OH in the presence of haloginating agent to obtain a compound of formula VI and treating a compound of formula VI with dehaloginating agent to obtain a compound of formula V by reducing a compound of formula V, followed by cylization to obtain compound of formula IV and separating the enantiomer and diastereomers from compound of formula IV to yield a compound of formula I. Compound of formula I is useful as an intermediate in the preparation of protease inhibitors, in particular broad spectrum HIV protease inhibitors, the present invention also relates to process for the preparation of Darunavir from (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol.