The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 23, 2014
Filed:
Feb. 15, 2013
Applicant:
Yunxiang Zhu, Wayland, MA (US);
Inventor:
Yunxiang Zhu, Wayland, MA (US);
Assignee:
Genzyme Corporation, Cambridge, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/47 (2006.01); C07H 11/04 (2006.01); A61K 38/17 (2006.01); A61K 31/7024 (2006.01); C12N 9/40 (2006.01); C12P 21/00 (2006.01);
U.S. Cl.
CPC ...
C12N 9/2465 (2013.01); A61K 31/7024 (2013.01); C07H 11/04 (2013.01); C07K 14/47 (2013.01); A61K 38/1709 (2013.01); C12P 21/005 (2013.01);
Abstract
Methods to introduce highly phosphorylated mannopyranosyl oligosaccharide derivatives containing mannose-6-phosphate (M6P), or other oligosaccharides bearing other terminal hexoses, to carbonyl groups on oxidized glycans of glycoproteins while retaining their biological activity are described. The methods are useful for modifying glycoproteins, including those produced by recombinant protein expression systems, to increase uptake by cell surface receptor-mediated mechanisms, thus improving their therapeutic efficacy in a variety of applications.