The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 23, 2014
Filed:
Apr. 27, 2009
Mark E. Anderson, Iowa City, IA (US);
Peter J. Mohler, Iowa City, IA (US);
Douglas R. Spitz, Jr., Iowa City, IA (US);
Jeffrey Robert Erickson, Davis, CA (US);
Mark E. Anderson, Iowa City, IA (US);
Peter J. Mohler, Iowa City, IA (US);
Douglas R. Spitz, Jr., Iowa City, IA (US);
Jeffrey Robert Erickson, Davis, CA (US);
University of Iowa Research Foundation, Iowa City, IA (US);
Abstract
Calcium/calmodulin dependent protein kinase II (CaMKII) has been found to be directly oxidized, and direct oxidation of CaMKII was observed to result in calcium independent activation of CaMKII. Antibodies that bind specifically to oxidized forms of CaMKII (oxCaMKII) were generated and were utilized to detect oxCaMKII in blood from: (1) mice with cancer; (2) mice with a knock out of the gene encoding methionine sulfoxide reductase; (3) mice injected with angiotensin II; (4) mice injected with bacterial endotoxin; (5) mice fed a pro-oxidant (ketogenic) diet; and (6) mice with cancer that had been treated with experimental therapy.