The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 23, 2014
Filed:
Apr. 22, 2013
Applicant:
Mount Sinai School of Medicine of New York University, New York, NY (US);
Inventors:
Assignee:
Mount Sinai School of Medicine of New York University, New York, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/445 (2006.01); A61K 31/70 (2006.01); C12N 9/40 (2006.01); A61K 31/7008 (2006.01);
U.S. Cl.
CPC ...
A61K 31/445 (2013.01); C12N 9/2465 (2013.01); A61K 31/7008 (2013.01);
Abstract
Method for enhancing in a mammalian cell the activity of an enzyme associated with Gaucher Disease by administering a competitive inhibitor of glucocerebrosidase in an amount effective to enhance the activity of the enzyme. Preferred compounds for use in the method are imino sugars and related compounds. In particular, C8-12-alkyl derivatives of N-alkyl-deoxynojirimycin, isofagomine compounds, and calystegine compounds are effective to enhance glucocerebrosidase activity.