The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 23, 2014
Filed:
May. 22, 2008
Melissa Kelley, Lafayette, CO (US);
Amanda Birmingham, Lafayette, CO (US);
Jon Karpilow, Boulder, CO (US);
Anastasia Khvorova, Boulder, CO (US);
Kevin Sullivan, Boulder, CO (US);
Melissa Kelley, Lafayette, CO (US);
Amanda Birmingham, Lafayette, CO (US);
Jon Karpilow, Boulder, CO (US);
Anastasia Khvorova, Boulder, CO (US);
Kevin Sullivan, Boulder, CO (US);
GE Healthcare Dharmacon, Inc., Lafayette, CO (US);
Abstract
The present disclosure provides non-naturally occurring miR-196a-2 miRNAs and non-naturally occurring miR-204 miRNAs. The non-naturally occurring miRNAs of the disclosure have mature strand sequences distinct from their endogenous counterparts. The disclosure also provides methods of selecting mature strand sequences that function optimally in non-naturally occurring miR-196a-2 miRNAs. The methods and compositions of the disclosure may be used to mediate gene silencing via the RNAi pathway.