The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 23, 2014
Filed:
Sep. 25, 2012
George Gorodeski, Beachwood, OH (US);
Wen Fu, Broadview Heights, OH (US);
George Gorodeski, Beachwood, OH (US);
Wen Fu, Broadview Heights, OH (US);
University Hospitals of Cleveland, Cleveland, OH (US);
Abstract
The present invention demonstrates that P2Xreceptor induced apoptosis may be specific for cancerous cells. Treatment with the P2Xligand BzATP, increased cellular apoptosis with no associated inflammatory changes or abnormal skin or systemic effects. In mice treated with DMBA/TPA, BzATP decreased papilloma skin formation. BzATP also induced involution of developed papillomas and stimulated apoptosis in keratinocytes outgrowing at the base of developed papillomas. These data show that (a) P2Xregulates apoptosis of epidermal cells; (b) in vivo, local administration of a drug that activates the P2Xreceptor can inhibit development and progression of epidermal premalignant lesions.