The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 23, 2014
Filed:
Aug. 30, 2006
Applicants:
John R. Murphy, Boston, MA (US);
Ryan Ratts, Boston, MA (US);
Inventors:
John R. Murphy, Boston, MA (US);
Ryan Ratts, Boston, MA (US);
Assignee:
Boston Medical Center Corporation, Boston, MA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/08 (2006.01);
U.S. Cl.
CPC ...
Abstract
The invention features methods for identifying compounds that inhibit cell death, and methods for identifying compounds that promote cell death, by blocking or accelerating, respectively, the translocation of the catalytic domain of toxins or transcription factors through the endosomal membrane into the cytosol of a cell. Also featured are methods for inhibiting cell death that include the administration of polypeptides that include a toxin consensus sequence recognized by one or more components of the cytosolic translocation factor complex.