The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 23, 2014
Filed:
Feb. 08, 2011
Charles Richardson, Bozeman, MT (US);
Robert F. Bargatze, Bozeman, MT (US);
Joel Haynes, Bozeman, MT (US);
Bryan Steadman, Bozeman, MT (US);
Charles Richardson, Bozeman, MT (US);
Robert F. Bargatze, Bozeman, MT (US);
Joel Haynes, Bozeman, MT (US);
Bryan Steadman, Bozeman, MT (US);
Takeda Vaccines, Inc., Bozeman, MT (US);
Abstract
The present invention provides polypeptides having a composite amino acid sequence derived from a consensus sequence representing the capsid proteins of two or more circulating strains of a non-enveloped virus. In particular, the invention provides virus-like particles comprising at least one composite polypeptide. Such virus-like particles have antigenic epitopes of two or more circulating strains of a non-enveloped virus and produce an increase in antisera cross-reactivity to one or more circulating strains of the non-enveloped virus. Methods of making composite virus-like particles and vaccine formulations comprising composite virus-like particles are also disclosed.