The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 23, 2014

Filed:

Oct. 25, 2007
Applicants:

Richard A. Mathies, Moraga, CA (US);

Robert Blazej, San Francisco, CA (US);

Palani Kumaresan, Berkeley, CA (US);

Inventors:

Richard A. Mathies, Moraga, CA (US);

Robert Blazej, San Francisco, CA (US);

Palani Kumaresan, Berkeley, CA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12M 1/00 (2006.01); C12M 1/34 (2006.01); C12M 3/00 (2006.01); G01N 15/06 (2006.01); B01D 57/02 (2006.01); C02F 1/40 (2006.01); B01L 3/00 (2006.01); G01N 27/447 (2006.01); G01N 1/40 (2006.01); B01L 7/00 (2006.01);
U.S. Cl.
CPC ...
G01N 27/44743 (2013.01); B01L 3/502784 (2013.01); B01L 3/502753 (2013.01); G01N 1/405 (2013.01); B01L 2200/0673 (2013.01); B01L 2400/0487 (2013.01); B01L 2200/027 (2013.01); B01L 2200/10 (2013.01); B01L 7/52 (2013.01); B01L 2400/0421 (2013.01); B01L 2200/0631 (2013.01); B01L 2300/0803 (2013.01); B01L 3/502715 (2013.01);
Abstract

Methods and microfluidic circuitry for inline injection of nucleic acids for capillary electrophoresis analysis are provided. According to various embodiments, microfabricated structures including affinity-based capture matrixes inline with separation channels are provided. The affinity-based capture matrixes provide inline sample plug formation and injection into a capillary electrophoresis channel. Also provided are methods and apparatuses for a microbead-based inline injection system for DNA sequencing.


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