The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 23, 2014

Filed:

Feb. 27, 2007
Applicants:

Lisa A. Paige, Hillsborough, NC (US);

Matthew W. Mitchell, Durham, NC (US);

Anne Evans, Durham, NC (US);

Don Harvan, Durham, NC (US);

Kay A. Lawton, Raleigh, NC (US);

Robert Brown, Needham, MA (US);

Merit Cudkowicz, Newton, MA (US);

Inventors:

Lisa A. Paige, Hillsborough, NC (US);

Matthew W. Mitchell, Durham, NC (US);

Anne Evans, Durham, NC (US);

Don Harvan, Durham, NC (US);

Kay A. Lawton, Raleigh, NC (US);

Robert Brown, Needham, MA (US);

Merit Cudkowicz, Newton, MA (US);

Assignees:

Massachusetts General Hospital, Boston, MA (US);

Metabolon, Inc., Durham, NC (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G01N 33/48 (2006.01); G01N 33/49 (2006.01); G01N 33/53 (2006.01); G01N 24/00 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
G01N 33/6896 (2013.01); G01N 2800/2835 (2013.01); G01N 2800/28 (2013.01); G01N 2800/56 (2013.01); G01N 2500/10 (2013.01);
Abstract

The present invention provides various biomarkers of amyotrophic lateral sclerosis (ALS). The present invention also provides various methods of using the biomarkers, including methods for diagnosis of ALS, methods of determining predisposition to ALS, methods of monitoring progression/regression of ALS, methods of assessing efficacy of compositions for treating ALS, methods of screening compositions for activity in modulating biomarkers of ALS, methods of treating ALS, as well as other methods based on biomarkers of ALS.


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