The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 23, 2014
Filed:
Jun. 25, 2007
John A. Kink, Madison, WI (US);
Laura E. Strong, Stoughton, WI (US);
Vladimir Trubetskoy, Middleton, WI (US);
Mark N. Shahan, Madison, WI (US);
John A. Kink, Madison, WI (US);
Laura E. Strong, Stoughton, WI (US);
Vladimir Trubetskoy, Middleton, WI (US);
Mark N. Shahan, Madison, WI (US);
Quintessence Biosciences, Inc., Madison, WI (US);
Abstract
The present invention relates generally to conjugates of human ribonucleases and water-soluble polymers, compositions comprising the conjugates and methods of using the same. In particular, the present invention provides conjugates of human ribonucleases and one or more water-soluble polymer compositions (e.g., to increase serum half-life and a pharmacokinetic profile, in vivo biological activity, stability, and/or reduce host immune response to the protein in vivo) as well as methods of using the conjugates in the therapy, treatment, and/or prevention of disease (e.g., cancer).