The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 23, 2014

Filed:

Jun. 26, 2009
Applicants:

Gord Adamson, Mississauga, CA;

David Bell, Mississauga, CA;

Steven Brookes, Mississauga, CA;

Inventors:

Gord Adamson, Mississauga, CA;

David Bell, Mississauga, CA;

Steven Brookes, Mississauga, CA;

Assignee:

Therapure Biopharma Inc., Mississauga, Ontario, CA;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/17 (2006.01); A61K 38/18 (2006.01); A61K 38/19 (2006.01); A61K 38/22 (2006.01); A61K 38/36 (2006.01); A61K 38/38 (2006.01); A61K 38/43 (2006.01); A61K 38/55 (2006.01); A61K 39/395 (2006.01); A61K 47/48 (2006.01); A61K 38/44 (2006.01); A61K 38/57 (2006.01); C07K 16/28 (2006.01); A61K 38/16 (2006.01); A61K 38/50 (2006.01); A61K 38/28 (2006.01); A61K 38/21 (2006.01); A61K 38/37 (2006.01); A61K 49/00 (2006.01);
U.S. Cl.
CPC ...
A61K 47/4823 (2013.01); A61K 47/48215 (2013.01); A61K 38/385 (2013.01); A61K 38/193 (2013.01); A61K 38/44 (2013.01); C12Y 305/01001 (2013.01); A61K 38/57 (2013.01); C07K 16/2896 (2013.01); A61K 38/166 (2013.01); A61K 38/50 (2013.01); A61K 38/28 (2013.01); A61K 38/212 (2013.01); A61K 38/37 (2013.01); A61K 49/0017 (2013.01); C12Y 107/03003 (2013.01);
Abstract

Method for preparing an oxidized polysaccharide-protein composition, by (a) oxidizing a polysaccharide with an oxidizing agent to form an oxidized polysaccharide where less than 20% of the oxidized units are comprised of alpha-hydroxy aldehyde units, (b) reacting the oxidized polysaccharide with a protein to form a composition comprising an oxidized polysaccharide-protein conjugate, and (c) maintaining the oxidized polysaccharide-protein conjugate composition by placing it in an environment where the temperature is less than 8° C. The oxidized polysaccharide and the protein are conjugated via one or more imine bonds, the oxidized polysaccharide-protein composition is soluble in aqueous solvent, and the composition is capable of releasing the protein.


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