The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 16, 2014
Filed:
Feb. 01, 2010
Alberto Guidi, Lonigo, IT;
Filippo Chiarello, Zermeghedo, IT;
Gianmauro Orru', Lonigo, IT;
Massimo Verzini, Caldiero, IT;
Livius Cotarca, Cervignano del Friuli, IT;
Jean-claude Kizirian, Paris, FR;
Elisenda Trepat Guixer, Barcelona, ES;
Francisco Marquillas Olondriz, Barcelona, ES;
Alberto Guidi, Lonigo, IT;
Filippo Chiarello, Zermeghedo, IT;
Gianmauro Orru', Lonigo, IT;
Massimo Verzini, Caldiero, IT;
Livius Cotarca, Cervignano del Friuli, IT;
Jean-Claude Kizirian, Paris, FR;
Elisenda Trepat Guixer, Barcelona, ES;
Francisco Marquillas Olondriz, Barcelona, ES;
Zach System S.p.A, Bresso, IT;
Abstract
The present invention relates to a process for the preparation of olopatadine and, more particularly, to an improved method of synthesizing olopatadine which comprises reacting a dibenz[b,e]oxepin-11-one derivative of formula (III) and a suitable reagent under Witting condition, and to the intermediate 11-[(Z)-3-(dimethylamino)-propylidene]-6-11-dihydrodibenz[b,e]-oxepin-2-acet-amide p-toluensulfonate salt.