The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 16, 2014
Filed:
Jun. 26, 2013
Gary Michael Ksander, Amherst, NH (US);
Erik Meredith, Hudson, MA (US);
Lauren Monovich, Belmont, MA (US);
Julien Papillon, Somerville, MA (US);
Fariborz Firooznia, Florham Park, NJ (US);
Qi-ying HU, Needham, MA (US);
Gary Michael Ksander, Amherst, NH (US);
Erik Meredith, Hudson, MA (US);
Lauren Monovich, Belmont, MA (US);
Julien Papillon, Somerville, MA (US);
Fariborz Firooznia, Florham Park, NJ (US);
Qi-Ying Hu, Needham, MA (US);
Novartis AG, Basel, CH;
Abstract
The present invention provides a compound of formula I: Said compound is inhibitor of aldosterone synthase and aromatase, and thus can be employed for the treatment of a disorder or disease mediated by aldosterone synthase or aromatase. Accordingly, the compound of formula I can be used in treatment of hypokalemia, hypertension, congestive heart failure, atrial fibrillation, renal failure, in particular, chronic renal failure, restenosis, atherosclerosis, syndrome X, obesity, nephropathy, post-myocardial infarction, coronary heart diseases, inflammation, increased formation of collagen, fibrosis such as cardiac or myocardiac fibrosis and remodeling following hypertension and endothelial dysfunction, gynecomastia, osteoporosis, prostate cancer, endometriosis, uterine fibroids, dysfunctional uterine bleeding, endometrial hyperplasia, polycystic ovarian disease, infertility, fibrocystic breast disease, breast cancer and fibrocystic mastopathy. Finally, the present invention also provides a pharmaceutical composition.