The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 16, 2014
Filed:
Mar. 06, 2006
Fan Wu, Halifax, CA;
Donald Weaver, Halifax, CA;
Chris Barden, Halifax, CA;
Christopher Mcmaster, Halifax, CA;
David Byers, Halifax, CA;
Annette Henneberry, Halifax, CA;
Fuqiang Ban, Halifax, CA;
Fan Wu, Halifax, CA;
Donald Weaver, Halifax, CA;
Chris Barden, Halifax, CA;
Christopher McMaster, Halifax, CA;
David Byers, Halifax, CA;
Annette Henneberry, Halifax, CA;
Fuqiang Ban, Halifax, CA;
Other;
Abstract
The synthesis and activity of novel LpxA inhibitors is described, these inhibitors present antibacterial activity. The compounds were designed based on a receptor model developed using the crystal structure of LpxA and are arranged to have a favorable binding interaction at the active site of the enzyme. In particular, the compounds present the following formula (I) where V, W, X, Y and Z can be independently C, S, N or O and P1, P2 and P3 are ligands to bind to the three points of the proposed pharmacophore model. They can be chosen from a variety of groups.