The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 16, 2014
Filed:
Jan. 23, 2013
Applicants:
Vern L. Schramm, New Rochelle, NY (US);
Anthony A. Sauve, Bronx, NY (US);
Inventors:
Vern L. Schramm, New Rochelle, NY (US);
Anthony A. Sauve, Bronx, NY (US);
Assignee:
Albert Einstein College of Medicine of Yeshiva University, Bronx, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/445 (2006.01); C12Q 1/34 (2006.01); C07D 241/24 (2006.01); C07D 213/83 (2006.01); A61K 38/00 (2006.01); A61K 31/4965 (2006.01); A61K 31/455 (2006.01); A61K 31/166 (2006.01); C07D 213/81 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4965 (2013.01); C12Q 1/34 (2013.01); C07D 241/24 (2013.01); C07D 213/83 (2013.01); A61K 38/005 (2013.01); A61K 31/455 (2013.01); A61K 31/166 (2013.01); C07D 213/81 (2013.01); G01N 2500/02 (2013.01);
Abstract
Compounds are disclosed which inhibit SIR2 base exchange more than deacetylation, thus enhancing SIR2 deacetylation activity. Methods of using the compounds for enhancing SIR2 deacetylation activity and increasing longevity of an organism are also disclosed. Methods for screening for compounds that enhance SIR2 deacetylation activity and increase longevity of an organism are additionally disclosed.