The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 16, 2014
Filed:
Jun. 02, 2011
Zhiyong Chen, San Diego, CA (US);
Christopher J. Creighton, San Diego, CA (US);
Mark Cunningham, San Diego, CA (US);
John Finn, San Diego, CA (US);
Mark Hilgers, San Diego, CA (US);
Michael Jung, Los Angeles, CA (US);
Lucy Aguirre Kohnen, Cambridge, MA (US);
Thanh Lam, San Diego, CA (US);
Xiaoming LI, San Diego, CA (US);
Mark Stidham, San Diego, CA (US);
Les Tari, San Diego, CA (US);
Michael Trzoss, San Diego, CA (US);
Junhu Zhang, San Diego, CA (US);
Zhiyong Chen, San Diego, CA (US);
Christopher J. Creighton, San Diego, CA (US);
Mark Cunningham, San Diego, CA (US);
John Finn, San Diego, CA (US);
Mark Hilgers, San Diego, CA (US);
Michael Jung, Los Angeles, CA (US);
Lucy Aguirre Kohnen, Cambridge, MA (US);
Thanh Lam, San Diego, CA (US);
Xiaoming Li, San Diego, CA (US);
Mark Stidham, San Diego, CA (US);
Les Tari, San Diego, CA (US);
Michael Trzoss, San Diego, CA (US);
Junhu Zhang, San Diego, CA (US);
Trius Therapeutics, Inc., San Diego, CA (US);
Abstract
The present disclosure provides compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R, Rand Z are as described herein. The disclosure also provides pharmaceutical compositions thereof; and methods for inhibiting DHFR activity; and methods for treating cell proliferative diseases, autoimmune disease, inflammatory disease or bacterial, fungal or parasitic infection by administering a compound of Formula I.