The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 16, 2014
Filed:
Jun. 05, 2008
Jean-pierre André Marc Bongartz, Turnhout, BE;
Lieven Meerpoel, Beerse, BE;
Gustaaf Maria Boeckx, Oud-Turnhout, BE;
Guy Rosalia Eugeen Van Lommen, Berlaar, BE;
Christophe Francis Robert Nestor Buyck, Hamme, BE;
Daniel Obrecht, Bättwil, CH;
Philipp Ermert, Allschwil, CH;
Anatol Luther, Binzen, DE;
Jean-Pierre André Marc Bongartz, Turnhout, BE;
Lieven Meerpoel, Beerse, BE;
Gustaaf Maria Boeckx, Oud-Turnhout, BE;
Guy Rosalia Eugeen Van Lommen, Berlaar, BE;
Christophe Francis Robert Nestor Buyck, Hamme, BE;
Daniel Obrecht, Bättwil, CH;
Philipp Ermert, Allschwil, CH;
Anatol Luther, Binzen, DE;
Janssen Pharmaceutica N.V., Beerse, BE;
Abstract
The invention further relates to a DGAT inhibitor of formula (I), including any stereochemically isomeric form thereof, wherein A represents CH or N; the dotted line represents an optional bond in case A represents a carbon atom; X represents —NR—C(═O)—; —Z—C(═O)—; —Z—NR—C(═O)—; —S(═O)p—; C(═S)—; —NR—C(═S)—; —Z—C(═S)—; —Z—NR—C(═S)—; —O—C(═O)—; —C(═O)—C(═O)—; Rrepresents a 5-membered monocyclic heterocycle containing at least 2 heteroatoms; a 6-membered aromatic monocyclic heterocycle; or a 5-membered heterocycle containing at least 2 heteroatoms fused with phenyl, cyclohexyl or a 5-or 6-membered heterocycle; wherein each of said heterocycles may optionally be substituted; Rrepresents R; Rrepresents Ccycloalkyl, phenyl, naphtalenyl, 2,3-dihydro-1,4-benzodioxinyl, 1,3-benzodioxlyl, 2,3-dihydrobenzofuranyl or a 6-membered aromatic heterocycle containing 1 or 2 N atoms, wherein said Ccycloalkyl, phenyl, naphtalenyl, 2,3-dihydro-1,4-benzo-dioxinyl, 1,3-benzodioxolyl, 2,3-dihydrobenzofuranyl or 6-membered aromatic heterocycle may optionally be substituted; a N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvate thereof. The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use as a medicine of said compounds.