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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8835403 B1

PDFFull Text
Date of Patent:
Sep. 16, 2014

Filed:

Feb. 25, 2005

Algin oligosaccharides and the derivatives thereof as well as the manufacture and the use of the same

Applicants:

Meiyu Geng, Qingdao, CN;

Huashi Guan, Qingdao, CN;

Xianliang Xin, Qingdao, CN;

Zhao Yang, Qingdao, CN;

Guangqiang Sun, Qingdao, CN;

Inventors:

Meiyu Geng, Qingdao, CN;

Huashi Guan, Qingdao, CN;

Xianliang Xin, Qingdao, CN;

Zhao Yang, Qingdao, CN;

Guangqiang Sun, Qingdao, CN;

Assignee:

Other;

Attorneys:

McCarter & English, LLP

Steven G. Davis

Wei Song

Primary Examiner:

Leigh Maier

Int. Cl.
CPC ...
A61K 31/7016 (2006.01); A61K 31/702 (2006.01); A61K 31/734 (2006.01); A61P 25/28 (2006.01); C07H 3/04 (2006.01); C07H 3/06 (2006.01); C08B 37/04 (2006.01); C08B 37/00 (2006.01); A61P 5/50 (2006.01);
U.S. Cl.
CPC ...
C08B 37/0084 (2013.01); C07H 3/06 (2013.01); C07H 3/04 (2013.01); C08B 37/0024 (2013.01);
Abstract

The present invention provides an alginate oligosaccharide and its derivatives with the degree of polymerization ranging from 2 to 22. The alginate oligosaccharide is composed of β-D-mannuronic acid linked by 1,4 glycosidic bonds. The derivatives with the reduced terminal in position 1 of carboxyl radical can be prepared by oxidative degradation. The present invention also provides a process for preparing the alginate oligosaccharide and its derivatives, which includes the procedures that an alginate solution is reacted for 2 to 6 h in an autoclave at pH 2-6 and the temperature of 100-120° C., and pH is adjusted to 7 after the reaction is stopped, after which the resultant oligosaccharide is oxidized in the presence of an oxidant to obtain an oxidative degradation product. The alginate oligosaccharide and its derivatives of the invention can be used in the manufacture of a medicament for the prophylaxis and treatment of AD and diabetes.

Find Patent Forward Citations

Geng, Meiyu. (2014). Algin oligosaccharides and the derivatives thereof as well as the manufacture and the use of the same (U.S. Patent No. 8835403). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/8835403

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