The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 16, 2014
Filed:
Jul. 23, 2009
Danette Dudley, Pacifica, CA (US);
John A. Flygare, Burlingame, CA (US);
Chudi Ndubaku, San Francisco, CA (US);
Danette Dudley, Pacifica, CA (US);
John A. Flygare, Burlingame, CA (US);
Chudi Ndubaku, San Francisco, CA (US);
Genentech, Inc., South San Francisco, CA (US);
Abstract
The invention provides novel compounds that are inhibitors of IAPs having the general formula: wherein X, X, X, Y, A, R, R, R, R, R, R, R, Rand Rare as described herein. The compouds of the invention may be used to induce apoptosis in cells (or sensitise cells to apoptosis) in which IAPs are overexpressed or otherwise implicated in resistance to normal apoptotic processes. Accordingly, the compounds may be provided in pharmaceutically acceptable compositions and used for the treatment cancers.