The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 16, 2014
Filed:
Feb. 28, 2012
Alan T. Remaley, Bethesda, MD (US);
Stephen J. Demosky, Gaithersburg, MD (US);
John A. Stonik, Gaithersburg, MD (US);
Marcelo J. A. Amar, Gaithersburg, MD (US);
Edward B. Neufeld, Washington, DC (US);
H. Bryan Brewer, Potomac, MD (US);
Fairwell Thomas, Rockville, MD (US);
Alan T. Remaley, Bethesda, MD (US);
Stephen J. Demosky, Gaithersburg, MD (US);
John A. Stonik, Gaithersburg, MD (US);
Marcelo J. A. Amar, Gaithersburg, MD (US);
Edward B. Neufeld, Washington, DC (US);
H. Bryan Brewer, Potomac, MD (US);
Fairwell Thomas, Rockville, MD (US);
Abstract
Disclosed herein are peptides or peptide analogs with multiple amphipathic α-helical domains that promote lipid efflux from cells via an ABCA1-dependent pathway. Also provided herein are methods of using multi-domain amphipathic α-helical peptides or peptide analogs to treat or inhibit dyslipidemic disorders. Methods for identifying non-cytotoxic peptides that promote ABCA1-dependent lipid efflux from cells are also disclosed herein.