The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 16, 2014
Filed:
Aug. 07, 2007
Marijke Haas, Groningen, NL;
Leonardus Dorothea Kluskens, Groningen, NL;
Anneke Kuipers, Haule, NL;
Rick Rink, Groningen, NL;
Sieger Adriaan Nelemans, Leens, NL;
Gert Nikolaas Moll, Groningen, NL;
Marijke Haas, Groningen, NL;
Leonardus Dorothea Kluskens, Groningen, NL;
Anneke Kuipers, Haule, NL;
Rick Rink, Groningen, NL;
Sieger Adriaan Nelemans, Leens, NL;
Gert Nikolaas Moll, Groningen, NL;
Applied Nanosystems B.V., Groningen, NL;
Abstract
The invention relates to analogs of angiotensins, in particular to cyclised analogs having Ang(1-8) agonistic or antagonistic activity and to cyclised Ang(1-7) analogs with agonistic or antagonistic activity and displaying improved proteolytic resistance compared to their linear counterparts. Provided is a cyclic angiotensin peptide analog comprising a thioether-bridge linkage between the amino acids corresponding to positions Tyrand Proin naturally occurring Angiotensin. Also provided is the use of analogs in therapy, for example hypertension.