The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 16, 2014
Filed:
May. 06, 2011
Applicants:
James Hickman, Orlando, FL (US);
Xiufang Guo, Oviedo, FL (US);
Inventors:
James Hickman, Orlando, FL (US);
Xiufang Guo, Oviedo, FL (US);
Assignee:
University of Central Florida Research Foundation, Inc., Orlando, FL (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 5/16 (2006.01); C12N 5/071 (2010.01); C12N 5/00 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0697 (2013.01); C12N 2535/10 (2013.01); C12N 2502/1335 (2013.01); C12N 2501/105 (2013.01); C12N 2501/58 (2013.01); C12N 2501/01 (2013.01); C12N 2502/081 (2013.01); C12N 2501/13 (2013.01); C12N 2500/90 (2013.01); C12N 2501/41 (2013.01); C12N 2501/385 (2013.01); C12N 2533/20 (2013.01);
Abstract
A method for forming neuromuscular junctions includes forming functional neuromuscular junctions between motoneurons and muscle cells by co-culturing one or more human motoneurons and one or more human muscle cells in a substantially serum-free medium. A synthetic mammalian neuromuscular junction includes a human motoneuron functionally linked to a human muscle cell in a substantially serum-free medium. An artificial substrate may be used to support the one or more neuromuscular junctions.