The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 16, 2014
Filed:
Nov. 02, 2012
Applicant:
The Nemours Foundation, Jacksonville, FL (US);
Inventors:
Sigrid Anne-Barbara Langhans, West Chester, PA (US);
Seung Joon Lee, Bear, DE (US);
Assignee:
The Nemours Foundation, Jacksonville, FL (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/574 (2006.01);
U.S. Cl.
CPC ...
Abstract
The presence of phosphorylated Cdc27 in cancer cells is utilized to identify patients likely to benefit from treatment with a chemotherapeutic agent that binds to, or binds to and crosslinks, phosphorylated Cdc27, e.g., curcumin, or to determine whether patients undergoing such treatment will continue to respond effectively. Candidate compounds are screened for anticancer effect by testing the ability to bind to or crosslink phosphorylated Cdc27.