The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 16, 2014
Filed:
Jul. 13, 2007
William D. Figg, Fairfax, VA (US);
Klaus Mross, Freiburg, DE;
Dirk Behringer, Bochum, DE;
Alex Sparreboom, Memphis, TN (US);
Tristan Sissung, Annandale, VA (US);
Stephan Mielke, Loehne, DE;
William D. Figg, Fairfax, VA (US);
Klaus Mross, Freiburg, DE;
Dirk Behringer, Bochum, DE;
Alex Sparreboom, Memphis, TN (US);
Tristan Sissung, Annandale, VA (US);
Stephan Mielke, Loehne, DE;
The United States of America as represented by the Secretary, Department of Health and Human Services, Washington, DC (US);
Universitätsklinikum Freiburg, Freiburg, DE;
Abstract
The present disclosure provides methods of identifying subjects having an increased likelihood of developing one or more adverse side effects resulting from administration of a microtubule-stabilizing agent. In particular examples, the method includes determining whether the subject has an ABCB1 predictive polymorphism for microtubule-stabilizing agent-induced toxicity, wherein the presence of such a polymorphism indicates that the subject has an increased risk of developing microtubule-stabilizing agent induced adverse effects. Examples of ABCB1 predictive polymorphisms include 2677G>T/A and 3435C>T. Also provided are methods of modifying microtubule-stabilizing agent therapy in a subject identified as having one or more ABCB1 predictive polymorphisms. Kits and isolated nucleic acid molecules that can be used in the disclosed methods are also provided.