The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 16, 2014
Filed:
Mar. 12, 2010
David Arteta, Derio, ES;
Marta Artieda, Derio, ES;
Diego Tejedor, Derio, ES;
Antonio Martinez, Derio, ES;
Laureano Simon, Derio, ES;
Bart A. Crusius, Amsterdam, NL;
Salvador Pena, Amsterdam, NL;
Madeleine Sombekke, Amsterdam, NL;
Bernard Uitdehaag, Amsterdam, NL;
Chris Polman, Amsterdam, NL;
David Arteta, Derio, ES;
Marta Artieda, Derio, ES;
Diego Tejedor, Derio, ES;
Antonio Martinez, Derio, ES;
Laureano Simon, Derio, ES;
Bart A. Crusius, Amsterdam, NL;
Salvador Pena, Amsterdam, NL;
Madeleine Sombekke, Amsterdam, NL;
Bernard Uitdehaag, Amsterdam, NL;
Chris Polman, Amsterdam, NL;
Brainco Biopharma S.L., Derio, ES;
Abstract
The invention relates to methods of evaluating MS severity based on analysis of single nucleotide polymorphisms (SNPs) and to products and kits for use in such methods. The methods include a method of assessing a multiple sclerosis disease severity phenotype in a human subject having multiple sclerosis, by determining the genotype of the subject at one or more positions of single nucleotide polymorphism (SNP) selected from: rs2107538, rs1137933, rs1318, rs2069763, rs423904, rs876493, rs10243024, rs10259085, rs1042173, rs10492503, rs10492972, rs12047808, rs12202350, rs12861247, rs13353224, rs1350666, rs1555322, rs1611115, rs17641078, rs1805009, rs2028455, rs2032893, rs2049306, rs2066713, rs2074897, rs2076530, rs2187668, rs2213584, rs2227139, rs2234978, rs2239802, rs2395182, rs260461, rs28386840, rs3087456, rs3135388, rs3741981, rs3756450, rs3781202, rs3787283, rs3808585, rs4128767, rs4404254, rs4473631, rs4680534, rs6077690, rs6457594, rs6570426, rs659366, rs6917747, rs7208257, rs7528684, rs7577925, rs762550, rs7956189, rs7995215, rs8049651, rs8702, rs9808753 and rs987107, and/or a SNP in linkage disequilibrium with any one of said SNPs.