The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 16, 2014
Filed:
Jun. 08, 2011
Yan Yang, Roslyn Heights, NY (US);
Rajiv Janjikhel, South Setauket, NY (US);
Niranjan Rao, Belle Mead, NJ (US);
Antonia Periclou, Jersey City, NJ (US);
Wattanaporn Abramowitz, West Windsor, NJ (US);
Mahendra G. Dedhiya, Pomona, NY (US);
Erhard Seiller, Nidderau, DE;
Bernhard Hauptmeier, Gelnhausen, DE;
Yan Yang, Roslyn Heights, NY (US);
Rajiv Janjikhel, South Setauket, NY (US);
Niranjan Rao, Belle Mead, NJ (US);
Antonia Periclou, Jersey City, NJ (US);
Wattanaporn Abramowitz, West Windsor, NJ (US);
Mahendra G. Dedhiya, Pomona, NY (US);
Erhard Seiller, Nidderau, DE;
Bernhard Hauptmeier, Gelnhausen, DE;
Forest Laboratories Holdings Limited, Hamilton, BM;
Abstract
The present invention relates to an immediate release solid oral dosage form containing 1-aminocyclohexanes, preferably memantine or neramexane, and optionally a pharmaceutically acceptable coating, wherein the active ingredient exhibits dose proportionality and is released at a dissolution rate of more than about 80% within about the first 60 minutes following entry of said form into a use environment. The dosage form is direct compressed and has a hardness within the range of between about 3 and about 40 Kp, exhibits an average Twithin the range of about 2 to about 8 hours with an active ingredient load within the range of about 2.5 to about 150 mg. The formulation allows for dose-proportional compositions for once daily or b.i.d. dosing, while maintaining a steady average range of T.