The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 16, 2014
Filed:
Dec. 28, 2009
Wendy J. Shaw, Richland, WA (US);
Clement R. Yonker, Kennewick, WA (US);
John L. Fulton, Richland, WA (US);
Barbara J. Tarasevich, Richland, WA (US);
James B. Mcclain, Raleigh, NC (US);
Doug Taylor, Franlinton, NC (US);
Wendy J. Shaw, Richland, WA (US);
Clement R. Yonker, Kennewick, WA (US);
John L. Fulton, Richland, WA (US);
Barbara J. Tarasevich, Richland, WA (US);
James B. McClain, Raleigh, NC (US);
Doug Taylor, Franlinton, NC (US);
Battelle Memorial Institute, Richland, WA (US);
Abstract
A medical implant device having a substrate with an oxidized surface and a silane derivative coating covalently bonded to the oxidized surface. A bioactive agent is covalently bonded to the silane derivative coating. An implantable stent device including a stent core having an oxidized surface with a layer of silane derivative covalently bonded thereto. A spacer layer comprising polyethylene glycol (PEG) is covalently bonded to the layer of silane derivative and a protein is covalently bonded to the PEG. A method of making a medical implant device including providing a substrate having a surface, oxidizing the surface and reacting with derivitized silane to form a silane coating covalently bonded to the surface. A bioactive agent is then covalently bonded to the silane coating. In particular instances, an additional coating of bio-absorbable polymer and/or pharmaceutical agent is deposited over the bioactive agent.