The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 16, 2014
Filed:
Jun. 14, 2011
Applicants:
Leslie A. Croy, Lakeville, NY (US);
Mark J. Paris, Mendon, NY (US);
Ernest S. Smith, Ontario, NY (US);
Inventors:
Leslie A. Croy, Lakeville, NY (US);
Mark J. Paris, Mendon, NY (US);
Ernest S. Smith, Ontario, NY (US);
Assignee:
Vaccinex, Inc., Rochester, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/22 (2006.01); C07K 14/475 (2006.01); G01N 33/53 (2006.01); A61K 51/10 (2006.01); A61K 47/48 (2006.01); A61K 39/395 (2006.01);
U.S. Cl.
CPC ...
Abstract
Provided are monoclonal antibodies and antigen binding fragments thereof that specifically bind vascular endothelial growth factor (VEGF). The anti-VEGF monoclonal antibodies block VEGF binding to its receptors (e.g., VEGFR1 and/or VEGFR2) and prevent phosphorylation of VEGFR2 by VEGF. Also provided are methods of using the monoclonal anti-VEGF antibodies for treatment of disease, including cancer.