The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 09, 2014
Filed:
Jan. 24, 2011
Applicants:
Michael Mizhiritskii, Rehovot, IL;
Ehud Marom, Kfar Saba, IL;
Inventors:
Michael Mizhiritskii, Rehovot, IL;
Ehud Marom, Kfar Saba, IL;
Assignee:
Mapi Pharma Ltd., Ness Ziona, IL;
Primary Examiner:
Int. Cl.
CPC ...
C07D 493/04 (2006.01);
U.S. Cl.
CPC ...
C07D 493/04 (2013.01);
Abstract
The present invention relates to a process for the preparation of darunavir, a nonpeptide protease inhibitor (PI), useful for the treatment of HIV/AIDS patients harboring multidrug-resistant HIV-1 variants that do not respond to previously existing HAART regimens. The present invention further relates to processes for the stereo-directed preparation of darunavir intermediates, in particular (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol and to certain novel intermediates obtained by such processes.