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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8829204 B1

PDFFull Text
Date of Patent:
Sep. 09, 2014

Filed:

Aug. 20, 2007

Modulators of atp-binding cassette transporters

Applicants:

Sara Hadida-ruah, La Jolla, CA (US);

Anna Hazlewood, San Diego, CA (US);

Peter Grootenhuis, San Diego, CA (US);

Fred Van Goor, San Diego, CA (US);

Ashvani Singh, San Diego, CA (US);

Jinglan Zhou, San Diego, CA (US);

Jason Mccartney, Cardiff by the Sea, CA (US);

Inventors:

Sara Hadida-Ruah, La Jolla, CA (US);

Anna Hazlewood, San Diego, CA (US);

Peter Grootenhuis, San Diego, CA (US);

Fred Van Goor, San Diego, CA (US);

Ashvani Singh, San Diego, CA (US);

Jinglan Zhou, San Diego, CA (US);

Jason McCartney, Cardiff by the Sea, CA (US);

Assignee:

Vertex Pharmaceuticals Incorporated, Boston, MA (US);

Attorneys:

Honigman Miller Schwartz and Cohn LLP

Christopher C. Forbes

Jonathan P. O'Brien

Primary Examiner:

Samantha Shterengarts

Int. Cl.
CPC ...
C07D 209/04 (2006.01); C07D 217/06 (2006.01); C07D 215/56 (2006.01); C07D 413/12 (2006.01); C07D 215/233 (2006.01); C07D 417/12 (2006.01); C07D 409/12 (2006.01); C07D 215/38 (2006.01); C07D 223/16 (2006.01); C07D 405/12 (2006.01); C07D 311/58 (2006.01); C07D 215/227 (2006.01); C07D 209/18 (2006.01); C07D 213/73 (2006.01); C07D 209/42 (2006.01); C07D 213/20 (2006.01); C07D 209/14 (2006.01); C07D 209/08 (2006.01); C07D 279/16 (2006.01); C07D 265/36 (2006.01); C07D 209/94 (2006.01); C07D 471/10 (2006.01); C07D 401/12 (2006.01); C07C 215/76 (2006.01); C07D 401/14 (2006.01);
U.S. Cl.
CPC ...
C07D 215/233 (2013.01); C07D 217/06 (2013.01); C07D 215/56 (2013.01); C07D 413/12 (2013.01); C07D 417/12 (2013.01); C07D 409/12 (2013.01); C07D 215/38 (2013.01); C07D 223/16 (2013.01); C07D 405/12 (2013.01); C07D 311/58 (2013.01); C07D 215/227 (2013.01); C07D 209/18 (2013.01); C07D 213/73 (2013.01); C07D 209/42 (2013.01); C07D 213/20 (2013.01); C07D 209/14 (2013.01); C07D 209/08 (2013.01); C07D 279/16 (2013.01); C07D 265/36 (2013.01); C07D 209/94 (2013.01); C07D 471/10 (2013.01); C07D 401/12 (2013.01); C07C 215/76 (2013.01); C07D 401/14 (2013.01);
Abstract

The present invention relates to modulators of ATP-Binding Cassette ('ABC') transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

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