The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 09, 2014
Filed:
Sep. 28, 2010
Mark T. Bilodeau, Landsdale, PA (US);
Melissa Egbertson, Ambler, PA (US);
Ahren Green, Landsale, PA (US);
John C. Hartnett, Philadelphia, PA (US);
Yiwei LI, Lower Gwynedd, PA (US);
Mark T. Bilodeau, Landsdale, PA (US);
Melissa Egbertson, Ambler, PA (US);
Ahren Green, Landsale, PA (US);
John C. Hartnett, Philadelphia, PA (US);
Yiwei Li, Lower Gwynedd, PA (US);
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Abstract
The present invention relates to compositions and methods that modulate at least one TRP family member. Specifically, the present invention relates to novel TRPA1 antagonists and their use in the treatment of pain such as chronic inflammatory and neuropathic pain. Compounds that can modulate one or more TRPA1 functions are useful in many aspects including, but not limited to, maintaining calcium homeostasis; maintaining sodium homeostasis; modulating intracellular calcium levels; modulating membrane polarization (membrane potential); modulating cation levels; and/or treating or preventing diseases, disorders, or conditions associated with calcium homeostasis, sodium homeostasis, calcium or sodium dyshomeostasis, or membrane polarization/hyperpolarization (including hypo and hyperexcitability), and/or treating or preventing diseases, disorders, or conditions associated with regulation or misregulation of TRPA1 expression or function. The present invention further relates to methods and compositions that antagonize both a function of TRPA1 and a function of one or more additional TRP channels.