The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 09, 2014
Filed:
Oct. 09, 2012
Alexander Vasillevich Ivashtchenko, Encinitas, CA (US);
Andrey Alexandrovich Ivashchenko, Moscow, RU;
Nikolay Filippovich Savchuk, Rancho Santa Fe, CA (US);
Alexander Vasillevich Ivashtchenko, Encinitas, CA (US);
Andrey Alexandrovich Ivashchenko, Moscow, RU;
Nikolay Filippovich Savchuk, Rancho Santa Fe, CA (US);
Other;
Abstract
The present invention relates to novel substituted 2-amino-3-(arylsulfonyl)pyrazolo[1,5-a]pyrimidines of general formula 1, to serotonin 5-HTreceptor antagonists, to novel drug substances and pharmaceutical compositions, to medicaments, methods for preparation thereof, and to methods for prophylaxis and treatment of various CNS diseases, pathogenesis of which is associated with disturbance of monoaminergic signaling pathways, more specifically over- or hypo-activation of serotonin 5-HTreceptors. In general formula 1 Rand Rindependently of each other represent C-Calkyl or phenyl; Rrepresents hydrogen or C-Calkyl; R, Rindependently of each other represent hydrogen, optionally substituted C-Calkyl or optionally substituted phenyl, or Rand Rtogether with the nitrogen atom they are attached to form optionally substituted heterocyclyl; Ar is aryl selected from phenyl, optionally substituted with Rthat is one or two optionally identical substituents selected from hydrogen, lower alkyl, trifluoromethyl or halogen; or optionally substituted 5-6-membered heteroaryl, containing as the heteroatom nitrogen or sulfur atom.