The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 09, 2014
Filed:
Dec. 10, 2004
Albert Deisseroth, San Diego, CA (US);
Yucheng Tang, San Diego, CA (US);
Wei-wei Zhang, San Diego, CA (US);
Xiang-ming Fang, San Diego, CA (US);
Albert Deisseroth, San Diego, CA (US);
Yucheng Tang, San Diego, CA (US);
Wei-Wei Zhang, San Diego, CA (US);
Xiang-Ming Fang, San Diego, CA (US);
MicroVAX, LLC, Manassas, VA (US);
Abstract
Provided are methods of generating an immune response to an antigen. The method comprises priming an individual by administering an expression vector encoding the antigen. The vectors comprises a transcription unit encoding a secretable fusion protein, the fusion protein containing an antigen and CD40 ligand. Administration of a fusion protein containing the antigen and CD40 ligand is used to enhance the immune response above that obtained by vector administration alone. The invention methods may be used to generate an immune response against cancer expressing a tumor antigen such as a mucin or human papilloma viral tumor antigen and to generate an immune response against an infectious agent. Also provided is a method for simultaneously producing the expression vector and the fusion protein.