The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 02, 2014

Filed:

Apr. 14, 2010
Applicants:

Steve Rosenberg, Oakland, CA (US);

Whittemore G. Tingley, San Francisco, CA (US);

Michael R. Elashoff, Redwood City, CA (US);

James A. Winrove, Sunnyvale, CA (US);

Inventors:

Steve Rosenberg, Oakland, CA (US);

Whittemore G. Tingley, San Francisco, CA (US);

Michael R. Elashoff, Redwood City, CA (US);

James A. Winrove, Sunnyvale, CA (US);

Assignee:

Cardiodx, Inc., Redwood City, CA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G06F 15/18 (2006.01); G06F 17/15 (2006.01); G06F 17/16 (2006.01); C12Q 1/68 (2006.01); G06Q 10/04 (2012.01); G06Q 30/02 (2012.01);
U.S. Cl.
CPC ...
C12Q 1/6883 (2013.01); G06Q 10/04 (2013.01); G06Q 30/02 (2013.01); C12Q 2600/158 (2013.01); C12Q 1/6809 (2013.01);
Abstract

Biomarkers useful for diagnosing and assessing physiological age are provided, along with kits for measuring their expression. The invention also provides predictive models, based on the biomarkers, as well as computer systems, and software embodiments of the models for scoring and optionally classifying samples. In a preferred embodiment, the biomarkers include a group of biomarkers whose expression levels are highly correlated to each other. In a preferred embodiment, expression levels of CD248; CD248 and SLC 1A7; CD248 and one, two, three or four of the group consisting of CCR7, B3GAT1, VSIG4 and LRRN3; or CD248, SLC1A7 and one, two, three or four of the group consisting of CCR7, B3GAT1, VSIG4 and LRRN3 are determined.


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