The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 02, 2014
Filed:
Mar. 21, 2012
Elena S. F. Berman, Mountain View, CA (US);
John R. Speakman, Stonehaven, GB;
Manish Gupta, Mountain View, CA (US);
Edward L. Melanson, Jr., Denver, CO (US);
Susan L. Fortson, Mountain View, CA (US);
Douglas S. Baer, Menlo Park, CA (US);
Elena S. F. Berman, Mountain View, CA (US);
John R. Speakman, Stonehaven, GB;
Manish Gupta, Mountain View, CA (US);
Edward L. Melanson, Jr., Denver, CO (US);
Susan L. Fortson, Mountain View, CA (US);
Douglas S. Baer, Menlo Park, CA (US);
ABB Research Ltd., Zurich, CH;
Abstract
A method of measuring energy expenditure in a living subject comprises: (a) administering a specified dose of doubly-labeled water (HO) to a living subject; (b) obtaining samples at three or more times of body water from the living subject; (c) measuringH/H,O/O andO/O ratios in each of the obtained samples using optical spectroscopy; and (d) determining (1) a combined value of flux of body water and exhaled carbon dioxide from a change in measuredO/O over time, (2) a value of flux of body water alone from a change in measuredH/H over time, and (3) a reference value of isotopic background fluctuation from a change in measuredO/O over time. UsingO measurements to estimate background fluctuations of theH andO decreases the required isotope dosing of subjects or decreases uncertainty at current dosing levels.