The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 02, 2014
Filed:
Oct. 02, 2009
Process for the synthesis of unprotected pentasaccharides from a protected pentasaccharide precursor
Applicants:
Ivan Lopez-belmonte Encina, Madrid, ES;
Rafael Ojeda Martinez DE Castilla, Madrid, ES;
Inventors:
Ivan Lopez-Belmonte Encina, Madrid, ES;
Rafael Ojeda Martinez De Castilla, Madrid, ES;
Assignee:
Laboratorios Farmacéutios Rovi, S.A., Madrid, ES;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C08B 37/00 (2006.01); C08B 37/10 (2006.01); C07H 5/04 (2006.01); C07H 5/06 (2006.01); A61K 31/727 (2006.01); C07H 15/04 (2006.01); C07H 15/18 (2006.01);
U.S. Cl.
CPC ...
C07H 15/04 (2013.01); C07H 15/18 (2013.01);
Abstract
Procedure for the synthesis of deprotected pentasaccharides from a protected precursor pentasaccharide through a reaction procedure having five stages whereamong is included an N-sulphation of amino groups and a hydrogenolysis of benzyl groups. Through this procedure a drastic reduction is achieved in the total synthesis time in comparison with the process traditionally employed, together with increased reproducibility thereof, permitting the standardization thereof.