The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 02, 2014
Filed:
Jan. 14, 2011
Peter Wipf, Pittsburgh, PA (US);
Natalia A. Belikova, Downers Grove, IL (US);
Jianfei Jiang, Pittsburgh, PA (US);
Joshua Pierce, La Jolla, CA (US);
Joel Greenberger, Sewickley, PA (US);
Michael Epperly, Pittsburgh, PA (US);
Valerian Kagan, Pittsburgh, PA (US);
Peter Wipf, Pittsburgh, PA (US);
Natalia A. Belikova, Downers Grove, IL (US);
Jianfei Jiang, Pittsburgh, PA (US);
Joshua Pierce, La Jolla, CA (US);
Joel Greenberger, Sewickley, PA (US);
Michael Epperly, Pittsburgh, PA (US);
Valerian Kagan, Pittsburgh, PA (US);
University of Pittsburgh—Of the Commonwealth System of Higher Education, Pittsburgh, PA (US);
Abstract
Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached to a mitochondria-targeting group. The compounds can be cross-linked into dimers without loss of activity. Also provided herein are methods, for preventing, mitigating and treating damage caused by radiation. The method comprises delivering a compound, as described herein, to a patient in an amount and dosage regimen effective to prevent, mitigate or treat damage caused by radiation.