The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 02, 2014
Filed:
Jun. 08, 2009
Said M. Sebti, Tampa, FL (US);
Jin Q. Cheng, Tampa, FL (US);
Andrew D. Hamilton, Guilford, CT (US);
Katherine Kayser-bricker, Branford, CT (US);
Said M. Sebti, Tampa, FL (US);
Jin Q. Cheng, Tampa, FL (US);
Andrew D. Hamilton, Guilford, CT (US);
Katherine Kayser-Bricker, Branford, CT (US);
University of South Florida, Tampa, FL (US);
Yale University, New Haven, CT (US);
Abstract
Disclosed herein is a species of peptide and non-peptide inhibitors of Akt, an oncogenic protein. Beginning with a residue of Akt target substrate GSK-3, the functional domains of the GSK-3 residue were characterized. Functionally homologous non-peptide groups were substituted for the amino acids of the GSK-3 creating a hybrid peptide-non-peptide and non-peptide compounds capable of binding to Akt. The non-peptide compounds show increased stability and rigidity compared to peptide counterparts and are less susceptible to degradation. The bound non-peptide compounds exhibit an inhibitory effect on Akt, similar to peptide-based Akt inhibitors.