The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 02, 2014
Filed:
Dec. 24, 2009
Shigeyuki Wakitani, Osaka, JP;
Hiroshi Fujita, Tokyo, JP;
Takeshi Ishimaru, Tokyo, JP;
Koji Yamamoto, Kanagawa, JP;
Yasuhiro Kurahashi, Kanagawa, JP;
Junichi Onaya, Tokyo, JP;
Hiroyuki Masuda, Tokyo, JP;
Shigeyuki Wakitani, Osaka, JP;
Hiroshi Fujita, Tokyo, JP;
Takeshi Ishimaru, Tokyo, JP;
Koji Yamamoto, Kanagawa, JP;
Yasuhiro Kurahashi, Kanagawa, JP;
Junichi Onaya, Tokyo, JP;
Hiroyuki Masuda, Tokyo, JP;
Seikagaku Corporation, Tokyo, JP;
Abstract
The inventions provides a method for immunologically determining a keratan sulfate level which method includes bringing an anti-keratan sulfate monoclonal antibody into contact with a biological sample, the anti-keratan sulfate monoclonal antibody exhibiting a relative reaction specificity between keratan sulfate-I and keratan sulfate-II represented by IC50of 0.4 to 5, to thereby provide a signal; and detecting keratan sulfate contained in the biological sample from the signal. On the basis of the method, the invention also provides a joint disease detection method and a method for assessing the effect of a remedy for a joint disease and a candidate substance therefor. Through these methods, a very small amount of keratan sulfate contained in a sample, can be determined. Particularly, these methods can determine, at high-sensitivity and high-specificity, the total keratan sulfate including keratan sulfate-I, which have been difficult to determine through a conventional technique. The methods also enables detect a joint disease and assess the effect of a remedy for a joint disease or a candidate substance therefor.