The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 02, 2014
Filed:
Nov. 11, 2011
Michael Neu, Edingen-Neckarahuasen, DE;
Markus Tschoepe, Hessheim, DE;
Carsten Weber, Maxdorf, DE;
Wolfgang Fraunhofer, Gurnee, IL (US);
Laura Redden, Glenview, IL (US);
Martin Gastens, Wachenheim, DE;
Alexander Feick, Allschwil, CH;
Michael Neu, Edingen-Neckarahuasen, DE;
Markus Tschoepe, Hessheim, DE;
Carsten Weber, Maxdorf, DE;
Wolfgang Fraunhofer, Gurnee, IL (US);
Laura Redden, Glenview, IL (US);
Martin Gastens, Wachenheim, DE;
Alexander Feick, Allschwil, CH;
Abbvie Biotechnology Ltd., Hamilton, BM;
Abstract
The invention provides a liquid aqueous pharmaceutical formulation comprising a human anti-TNFa antibody, or antigen-binding portion thereof, which reduces pain associated with injection in a subject by at least about 50% when compared to injecting an otherwise identical formulation comprising at least one salt and/or at least one buffer. The invention also provides a liquid aqueous pharmaceutical formulation comprising a human anti-TNFa antibody, or antigen-binding portion thereof, having increased bioavailability upon subcutaneous administration into a subject. The formulation may comprise a therapeutic protein, such as a human anti-TNF-alpha antibody, or an antigen-binding portion thereof, or a biosimilar thereof.