The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 26, 2014
Filed:
Jan. 12, 2010
Lakshmi Anu Prabhavathi Devi Bethala, Hyderabad, IN;
Nadpi Gangadhar Katkam, Hyderabad, IN;
Vijayalakshmi Kunkuma, Hyderabad, IN;
Ramakrishna Sistla, Hyderabad, IN;
Madhusudhana Kuncha, Hyderabad, IN;
Vamanrao Diwan Prakash, Hyderabad, IN;
Badari Narayana Prasad Rachapudi, Hyderabad, IN;
Lakshmi Anu Prabhavathi Devi Bethala, Hyderabad, IN;
Nadpi Gangadhar Katkam, Hyderabad, IN;
Vijayalakshmi Kunkuma, Hyderabad, IN;
Ramakrishna Sistla, Hyderabad, IN;
Madhusudhana Kuncha, Hyderabad, IN;
Vamanrao Diwan Prakash, Hyderabad, IN;
Badari Narayana Prasad Rachapudi, Hyderabad, IN;
Council of Scientific & Industrial Research, New Delhi, IN;
Abstract
Hexadecyl cis-9-tetradecenoate commonly known as Cetyl myristoleate (CMO) is being used for the treatment of osteoarthritis and other joint inflammatory diseases, cis-9-Tetradecenoic acid (cis-9-myristoleic acid) is the main precursor for the preparation of CMO. As there are limited natural plant sources for cis-9-tetradecenoic acid, the present invention aimed at the synthesis of cis-9-tetradecenoic acid methyl ester from oleic acid methyl ester. As oleic acid is not available in pure form, this has to be isolated from oleic acid-rich oils like olive oil. cis-10-Tetradecenoic acid methyl ester, an isomer of cis-9-tetradecenoic acid was also prepared from undecenoic acid methyl ester, a derivative of castor oil. Undecenoic acid is easily available commercially in pure form. Hexadecyl cis-9-tetradecenoate and hexadecyl c/s-10-tetradecenoate were prepared by enzymatic transesterification of cis-9-tetradecenoic acid methyl ester and cis-10-tetradecenoic acid methyl ester with 1-hexadecanol (cetyl alcohol) respectively. Both the isomers of cetyl myristoleate were evaluated for anti arthritis, blocking inflammation and reduction of adjuvant-induced arthritis in rats.