The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 26, 2014

Filed:

Aug. 13, 2013
Applicants:

Sean Dalziel, San Francisco, CA (US);

Leticia M. Preza, San Francisco, CA (US);

Miroslav Rapta, San Carlos, CA (US);

Pierre-jean Colson, San Francisco, CA (US);

Inventors:

Sean Dalziel, San Francisco, CA (US);

Leticia M. Preza, San Francisco, CA (US);

Miroslav Rapta, San Carlos, CA (US);

Pierre-Jean Colson, San Francisco, CA (US);

Assignee:

Theravance Biopharma R&D IP, LLC, South San Francisco, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 221/02 (2006.01); A61K 45/06 (2006.01); A61K 31/485 (2006.01); C07D 451/02 (2006.01); A61K 31/46 (2006.01);
U.S. Cl.
CPC ...
C07D 451/02 (2013.01); A61K 45/06 (2013.01); A61K 31/485 (2013.01); A61K 31/46 (2013.01);
Abstract

The invention provides a crystalline sulfate salt of 3-endo-(8-{2-[cyclohexylmethyl-((S)-2,3-dihydroxy-propionyl)amino]ethyl}-8-aza-bicyclo[3.2.1]oct-3-yl)benzamide or a solvate thereof. The invention also provides pharmaceutical compositions comprising such crystalline salt forms, methods of using such crystalline salt forms to treat diseases associated with mu opioid receptor activity, and processes useful for preparing such crystalline salt forms.


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