The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 26, 2014

Filed:

Aug. 03, 2011
Applicants:

David Banner, Basel, CH;

Emanuele Gabellieri, Siena, IT;

Wolfgang Guba, Muellheim, DE;

Hans Hilpert, Muenchenstein, CH;

Benoit Hornsperger, Altkirch, FR;

Roland Humm, Auggen, DE;

Harald Mauser, Birsfelden, CH;

Alexander V. Mayweg, Basel, CH;

Robert Narquizian, Zaessingue, FR;

Emmanuel Pinard, Linsdorf, FR;

Mark Rogers-evans, Bottmingen, CH;

Thomas Woltering, Freiburg, DE;

Wolfgang Wostl, Grenzach-Wyhlen, DE;

Inventors:

David Banner, Basel, CH;

Emanuele Gabellieri, Siena, IT;

Wolfgang Guba, Muellheim, DE;

Hans Hilpert, Muenchenstein, CH;

Benoit Hornsperger, Altkirch, FR;

Roland Humm, Auggen, DE;

Harald Mauser, Birsfelden, CH;

Alexander V. Mayweg, Basel, CH;

Robert Narquizian, Zaessingue, FR;

Emmanuel Pinard, Linsdorf, FR;

Mark Rogers-Evans, Bottmingen, CH;

Thomas Woltering, Freiburg, DE;

Wolfgang Wostl, Grenzach-Wyhlen, DE;

Assignees:

Hoffmann-La Roche Inc., Nutley, NJ (US);

Siena Biotech S.p.A., Siena, IT;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 239/22 (2006.01); A61K 31/513 (2006.01);
U.S. Cl.
CPC ...
C07D 239/22 (2013.01); A61K 31/513 (2013.01);
Abstract

This invention relates to compounds of the formula wherein Rto Rare as described below, or to pharmaceutically acceptable salts thereof. These compounds are BACE2 inhibitors and can be used as medicaments for the therapeutic and/or prophylactic treatment of diseases such as diabetes, particularly type 2 diabetes, and other metabolic disorders.


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