The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 26, 2014

Filed:

Sep. 03, 2009
Applicants:

Henry Yu, Wellesley, MA (US);

Lizbeth Celeste DE Selm, Melrose, MA (US);

Xuliang Jiang, Braintree, MA (US);

Benny C. Askew, Jr., Marshfield, MA (US);

Srinivasa R. Karra, Pembroke, MA (US);

Andreas Goutopoulos, Boston, MA (US);

Inventors:

Henry Yu, Wellesley, MA (US);

Lizbeth Celeste De Selm, Melrose, MA (US);

Xuliang Jiang, Braintree, MA (US);

Benny C. Askew, Jr., Marshfield, MA (US);

Srinivasa R. Karra, Pembroke, MA (US);

Andreas Goutopoulos, Boston, MA (US);

Assignee:

Merck Patent GmbH, Darmstadt, DE;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/529 (2006.01); C07D 239/42 (2006.01); C07D 487/08 (2006.01); C07D 487/18 (2006.01); C07D 498/08 (2006.01); C07D 498/18 (2006.01); C07D 513/08 (2006.01); C07D 513/18 (2006.01); C07D 515/08 (2006.01);
U.S. Cl.
CPC ...
C07D 498/08 (2013.01); C07D 513/08 (2013.01); C07D 498/18 (2013.01); C07D 515/08 (2013.01); C07D 487/08 (2013.01); C07D 513/18 (2013.01); C07D 487/18 (2013.01);
Abstract

Macrocyclic derivative compounds that inhibit protein kinase enzymes are disclosed along with pharmaceutical compositions comprising these compounds and methods for synthesizing the same. Such compounds have utility in the treatment of proliferative diseases resulting from unregulated and/or disturbed kinase activity such as cancers, psoriasis, viral and bacterial infections, inflammatory and autoimmune diseases.


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