The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 26, 2014
Filed:
Jul. 17, 2009
Applicant:
Neil M. Bodie, Agoura Hills, CA (US);
Inventor:
Neil M. Bodie, Agoura Hills, CA (US);
Assignee:
Trinity Therapeutics, Inc., Agoura Hills, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/10 (2006.01); C07K 7/08 (2006.01); C07K 7/00 (2006.01); C07K 16/10 (2006.01);
U.S. Cl.
CPC ...
A61K 38/10 (2013.01); C07K 7/08 (2013.01); C07K 7/00 (2013.01); C07K 16/1081 (2013.01);
Abstract
Polypeptides and other compounds that can bind specifically to the C2-C3 cleft of an immunoglobulin molecule, as well as methods for using such polypeptides and compounds to inhibit Fc-mediated immune complex formation in viral infection, are described. For example, polypeptides and other compounds can be used to inhibit binding of DF-associated, immune-complexed IgG anti-DF viron(s) or DV viral antigens to FγR, ADE of DF/DHF/DSS infections by inhibition of DF viral antigen binding to immune complexed IgG, FγR and immune complexed IgG mC1q (membrane C1q) or soluble C1q binding.